Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Parasin I TFA | 219552-69-9 | 99.8% | 2114.33 | 5 MG
Parasin I (TFA) is a 19-amino acid histone H2A-derived peptide isolated from the skin of the catfish, exhibiting antimicrobial activity. It is intended for research use only and not for patient administration.
- 19-amino acid histone H2A-derived peptide
- Isolated from the skin of catfish
- Shows antimicrobial activity
- White to off-white solid appearance
- Sequence: Lys-Gly-Arg-Gly-Lys-Gln-Gly-Gly-Lys-Val-Arg-Ala-Lys-Ala-Lys-Thr-Arg-Ser-Ser
- Initial source: Animals, the skin mucus of wounded catfish
Medchemexpress LLC DLPLTFGGGTK TFA | MFCD34187350 | 98.1% | 1219.26 | 1 MG
DLPLTFGGGTK TFA is a synthetic peptide, presented as a white to off-white solid. It is a surrogate peptide for pembrolizumab identification and has been tested to comply with given specifications. This high-purity product (98.11%) is intended for research use only.
- White to off-white solid
- Surrogate peptide for pembrolizumab identification
- High purity of 98.11%
- Molecular weight of 1219.26
- Intended for research use
Medchemexpress LLC Cpn-267 tfa | 1279.27 | 1 MG
Cpn-267 tfa is a selective agonist for neuromedin U receptor 1 (NMUR1) with an EC50 of 0.25 nM. This compound has been shown to suppress body weight gain in mice, suggesting its potential use in the study of obesity. It is provided as a solid for research applications.
- Selective NMUR1 agonist.
- Potent activity at nanomolar concentrations.
- Demonstrated suppression of body weight gain in animal models.
- Suitable for obesity research.
Medchemexpress LLC 7-TFA-ap-7-Deaza-dA | 178420-75-2 | 98.8% | 399.32 | 1 ML
7-TFA-ap-7-Deaza-dA is a modified nucleoside that can be used in the synthesis of deoxyribonucleic acid or nucleic acid. It functions as a click chemistry reagent, containing an alkyne group that undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules.
- Modified nucleoside.
- Can be used in the synthesis of deoxyribonucleic acid or nucleic acid.
- Functions as a click chemistry reagent.
- Contains an alkyne group for reactions.
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups.
Apexbio Technology LLC 2X hyperfusion plus master mix (With dye) 10X1ml
Our 2X Hyperfusion Plus Master Mix (With dye) product offers high fidelity strong amplification performance and faster extension speed simultaneously making it suitable for most PCR applications Hyperfusion Plus DNA Polymerase is created by fusing a Pyrococcus-like proofreading polymerase with a DNA binding domain providing increased fidelity and speed Hyperfusion Plus DNA Polymerase owns high fidelity 50 times lower error rate than Taq DNA Polymerase and 6 times lower error compared to Pyrococcus Furious DNA Polymerase Experimental results demonstrate that our Hyperfusion Plus polymerase can amplify genome fragments as long as 20 1 kb 2X Hyperfusion plus master mix (With dye) is a ready-to-use 2 premix solution containing polymerase dNTPs an already optimized buffer system and dye Our mix is ideal for any detection and the PCR product can be directly electrophoresed after the amplification without the need to add a loading buffer
Medchemexpress LLC PLP (180-199) TFA | 99.22% | 2085.34 (free base) | 1 MG
PLP (180-199) TFA is the TFA salt form of PLP (180-199). It induces the activation and differentiation of T cells and induces experimental autoimmune encephalomyelitis (EAE) in mouse models.
- Activates and differentiates T cells
- Induces experimental autoimmune encephalomyelitis (EAE) in mouse models
- Molecular weight: 2085.34 (free base)
- Purity: 99.22%
- Sealed storage, away from moisture
- Powder storage: -80°C for 2 years, -20°C for 1 year
- In solvent storage: -80°C for 6 months, -20°C for 1 month
![Medchemexpress LLC Benzamide, N-(3S)-1-azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxy-, 2,2,2-trifluoroacetate (1:1) | 1336913-03-1 | 99.85% | 404.38 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000438128-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC Benzamide, N-(3S)-1-azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxy-, 2,2,2-trifluoroacetate (1:1) | 1336913-03-1 | 99.85% | 404.38 | 1 ML
PSEM 89S TFA is a selective and brain-penetrant agonist for ion channels, orthogonally selective for Q79G and L141F. It is intended for research use only.
- Activates layer 2/3 cortical neurons expressing PSAML141F,Y115F-5HT3 high conductance (HC).
- Reversibly silenced transfected neurons by reducing cellular input resistance.
- Strongly reduces photostimulation-evoked feeding in mice expressing PSAML141F,Y115F-glycine receptor (GlyR).
- Shows good brain penetrance in mice after minimally invasive intraperitoneal administration.
- Almost completely suppressed fos in ChR2-expressing neurons in male Agrp-cre mice.
- Rises rapidly in serum and brain, and is mostly cleared from both compartments in 1 hour in C57BL/6 mice.
Medchemexpress LLC RC-3095 TFA | 1217463-61-0 | 1220.34 | 1 MG
RC-3095 TFA | 1217463-61-0 | 1220.34 | 1 MG
TARGETMOL CHEMICALS INC Atecegatran TFA 1MG
Also available in 5 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Atecegatran TFA is often used as an anticoagulant and can be used to treat cardiovascular disease. Purity 98.5%
Apexbio Technology LLC 10 mM dNTP Mixture 5x1ml
10 mM dNTP (2 -deoxynucleoside 5 -triphosphate) Mixture is an equimolar premixed aqueous solution containing four nucleotides (dATP dCTP dGTP and dTTP) each at a concentration of 10 mM The product is prepared as an aqueous solution titrated with NaOH to a neutral pH of 7 0
Apexbio Technology LLC SUPER-TDU-TFA-1MG
Super-TDU TFA (CAS No 1599441-71-0) is an advanced compound frequently used in the biomedical research field particularly known for its role in investigating intracellular signaling pathways and targeting specific cellular proteins Originating from cutting-edge chemical synthesis it primarily operates by modulating specific enzymatic pathways making it a crucial tool for studying cellular mechanisms Known for its high potency this compound exhibits in vitro activity ranging from nanomolar to low micromolar concentrations facilitating precise experimental data It is widely employed in various research applications including cell models and animal studies and is integral to drug screening processes for identifying potential therapeutic candidates Experimental concentrations typically depend on the specific research design