Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC GpTx-1 TFA | 99.6% | 4073.82 (free base) | 1 MG
GpTx-1 TFA is a peptide-based NaV1.7 sodium channel antagonist isolated from the venom of the Chilean spider Grammostola porter. It demonstrates potent inhibitory activity against the NaV1.7 channel with an IC50 value of 10 nM. It also exhibits excellent selectivity for NaV1.4 (IC50 = 0.301 μM) and NaV1.5 (IC50 = 4.20 μM), demonstrating >20-fold and >950-fold selectivity, respectively. This product is for research use only.
- Potent inhibitory activity against NaV1.7 channel with an IC50 value of 10 nM.
- Exhibits >20-fold selectivity for NaV1.4 (IC50 = 0.301 μM).
- Exhibits >950-fold selectivity for NaV1.5 (IC50 = 4.20 μM).
- Isolated from the venom of the Chilean spider Grammostola porter.
Medchemexpress LLC Alpha-Melanocyte-Stimulating Hormone TFA | 171869-93-5 | 98.5% | 1 MG
α-MSH TFA (α-Melanocyte-Stimulating Hormone TFA) is an endogenous neuropeptide and a melanocortin receptor 4 (MC4R) agonist. It exhibits anti-inflammatory and antipyretic activities and is a post-translational derivative of pro-opiomelanocortin (POMC).
- Endogenous neuropeptide
- MC4R agonist with anti-inflammatory and antipyretic activities
- Post-translational derivative of pro-opiomelanocortin (POMC)
- Modulates CNS inflammation by acting directly on melanocortin receptors in glial cells
- Modulates NFκB activation
- Inhibits translocation of transcription factor κB to the nucleus
Medchemexpress LLC PKA RII peptide TFA | 99.7% | 2226.37 | 10 MG
PKA RII peptide TFA is a PKA substrate that, after being phosphorylated at the serine residue, can be used for the detection of calcineurin activity. It is for research use only.
- Solid appearance, white to off-white color.
- Sequence: Asp-Leu-Asp-Val-Pro-Ile-Pro-Gly-Arg-Phe-Asp-Arg-R-Val-Ser-Val-Ala-Ala-Glu.
- Sequence shortening: DLDVPIPGRFDRRVSVAAE.
- Store as powder at -80°C for 2 years or -20°C for 1 year.
- Store in solvent at -80°C for 6 months or -20°C for 1 month (sealed storage, away from moisture).
- Soluble in H2O at 25 mg/mL (11.23 mM, requires ultrasonic).
Medchemexpress LLC CCZ01048 TFA | 98.5% | 1622.75 | 5 MG
CCZ01048 TFA is an α-MSH analogue that exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a Ki of 0.31 nM. It shows rapid internalization into B16F10 melanoma cells and demonstrates high in vivo stability, making it a promising candidate for PET imaging of malignant melanoma.
- α-MSH analogue
- High binding affinity to melanocortin 1 receptor (MC1R) with a Ki of 0.31 nM
- Rapid internalization into B16F10 melanoma cells
- High in vivo stability
- Promising candidate for PET imaging of malignant melanoma
Medchemexpress LLC Ql9 tfa | 95.91% | 5 MG
QL9 (QLSPFPFDL) TFA is a high-affinity alloantigen for the 2C T cell receptor (TCR), intended for research use only.
- High-affinity alloantigen
- Specific for the 2C T cell receptor (TCR)
- Suitable for research applications
Medchemexpress LLC Larllt tfa | 99.9% | 799.88 | 25 MG
LARLLT TFA is an EGFR-binding peptide with potential for research into EGFR overexpressing cancers. This peptide is suitable for studies involving lung, ovarian, and colorectal cancer.
- EGFR-binding peptide
- Potential for research into EGFR overexpressing cancers
- Suitable for lung, ovarian, and colorectal cancer studies
Medchemexpress LLC Calcitonin, eel TFA | 99.9% | 3528.89 | 5 MG
Calcitonin, eel TFA is a thyroid hormone peptide that plays a role in regulating calcium homeostasis. It is frequently used in research concerning postmenopausal osteoporosis. In vitro studies show that Calcitonin, eel stimulates phosphoinositide hydrolysis and prolactin release in cultured anterior pituitary cells more effectively than salmon calcitonin. However, it does not inhibit prolactin release under conditions stimulated by thyrotropin releasing hormone (TRH).
- Contributes to the regulation of calcium homeostasis.
- Widely used in postmenopausal osteoporosis research.
- Effectively induces a concentration-dependent stimulation of phosphoinositide hydrolysis in vitro.
- Stimulates prolactin release in cultured anterior pituitary cells in vitro.
- High purity of 99.91%.
Medchemexpress LLC Pep2-8 TFA | 98.8% | 1715.85 (free base) | 1 MG
Pep2-8 is a peptide that enhances the antagonistic activity of proprotein convertase subtilin/kexin type 9 (PCSK9). It binds to C-terminally truncated PCSK9 and restored LDL uptake of PCSK9-treated HepG2 cells to approximately 90% of control activity at a concentration of 50 μM.
- Enhances antagonistic activity of proprotein convertase subtilin/kexin type 9 (PCSK9)
- Binds to C-terminally truncated PCSK9
- Restores LDL uptake of PCSK9-treated HepG2 cells to approximately 90% of control activity
- For research use only
Medchemexpress LLC CGGRGD TFA | 98.7% | 677.61 | 5 MG
CGGRGD TFA is a derivative of RGD (Arginine-Glycine-Aspartic acid) that includes cysteine at its N-terminal. This product is intended for research applications only and not for human use. It is referenced in publications regarding the functionalization of PCL fibrous membranes with RGD peptide.
- Biological activity: a derivative of RGD with cysteine at its N-terminal
- Purity: 98.66%
- Molecular weight: 677.61
- Formula: C21H34F3N9O11S
- Appearance: solid
- Color: white to off-white
- Sequence: Cys-Gly-Gly-Arg-Gly-Asp
- Sequence shortening: CGGRGD
- Solubility in vitro: soluble in DMSO at 100 mg/mL (147.58 mM); ultrasonic assistance may be needed, and newly opened DMSO is recommended due to hygroscopic impact on solubility
Medchemexpress LLC G7-18NATE TFA | 98.1% | 1417.50 | 1 MG
G7-18NATE TFA is a peptide inhibitor of Grb7. It binds to the Grb7-SH2 domain with micromolar affinity (Kd = 18.1 μM). G7-18NATE TFA inhibits cell proliferation, motility, cell invasion, and 3D culture formation in several cancer cell lines.
- Peptide inhibitor of Grb7
- Binds to the Grb7-SH2 domain with micromolar affinity (Kd = 18.1 μM)
- Inhibits cell proliferation, motility, cell invasion, and 3D culture formation in several cancer cell lines
Medchemexpress LLC IA9 TFA (human TREM-2 182-190 TFA) | 98.9% | 1001.31 (free acid) | 5 MG
IA9 TFA is a potent, CNS-penetrant inhibitor of Triggering Receptor Expressed on Myeloid cells 2 (TREM-2). It is capable of reducing proinflammatory cytokines and mitigating joint inflammation and damage in a Collagen-induced arthritis mouse model. This compound is suitable for neuroinflammation PET imaging and research related to rheumatoid arthritis and neuroinflammation.
Features and Benefits
- Potent CNS-penetrant TREM-2 inhibitor.
- Diminishes the release of proinflammatory cytokines.
- Suppresses joint inflammation and damage in experimental arthritis.
- Can be used for neuroinflammation PET imaging.
- Applicable for rheumatoid arthritis and neuroinflammation research.
TARGETMOL CHEMICALS INC Atecegatran TFA 1MG
Also available in 5 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Atecegatran TFA is often used as an anticoagulant and can be used to treat cardiovascular disease. Purity 98.5%
Medchemexpress LLC Clovibactin TFA | 97.1% | 903.08 (free base) | 500 UG
Clovibactin TFA is the TFA salt form of Clovibactin. It acts as an antibiotic against drug-resistant bacterial pathogens without detectable resistance, functioning by inhibiting cell wall synthesis, specifically targeting pyrophosphate of peptidoglycan precursors.
- Inhibits cell wall synthesis.
- Targets pyrophosphate of peptidoglycan precursors.
- Effective against Staphylococcus strains with MICs of 0.125-2 μg/mL.
- For research use only.
- Molecular weight: 903.08 (free base).
- Formula: C43H70N10O11.xC2HF3O2.
- Appearance: Solid, white to off-white.
- Solubility: DMSO: 100 mg/mL (Need ultrasonic).
Medchemexpress LLC Reltecimod TFA | 1447799-33-8 | ≥98% | 1037.19 | 25 MG
Reltecimod TFA is a T cell-specific surface glycoprotein CD28 (TP44) antagonist. It demonstrates good resistance to various bacterial infections, bacterial exotoxins and endotoxins, and ionizing radiation. Reltecimod TFA modulates the inflammatory response by targeting and attenuating the critical CD28/B7-2 costimulatory pathway without inhibiting it. It may be used to study necrotizing soft tissue infections (NSTIs).
- T cell-specific surface glycoprotein CD28 (TP44) antagonist
- Good resistance to different bacterial infections, bacterial exotoxins and endotoxins, and ionizing radiation
- Modulates inflammatory response by attenuating the CD28/B7-2 costimulatory pathway
- May be utilized to study necrotizing soft tissue infections (NSTIs)
- Increases survival rate of mice harboring several bacterial infections (at 1.25-5 mg/kg; iv)
Medchemexpress LLC LIH383 | 2866266-58-0 | 99.8% | 997.22 | 1 MG
LIH383 is an agonist of ACKR3 (CXCR7) with an EC50 of 0.61 nM. It efficiently induces the recruitment of β-arrestin to ACKR3 but does not trigger typical G protein signaling.
- Agonist of ACKR3 (CXCR7)
- Efficiently induces recruitment of β-arrestin to ACKR3
- Does not trigger typical G protein signaling